When someone wants to get started with taking a GH-stimulating peptide, there are so many options that trying to find out which ones are the best can turn out to be an incredibly intimidating task.
That’s why we’ve done the research and curated this list of the 8 best HGH peptides that stimulate growth hormone in safe and effective ways.
For each one, we’ll give you a solid foundational look at what the peptide is, what it does, and how it does it, as well as some of the ancillary benefits that may be observed, if any.
Learn more about the 8 best HGH peptides below:
#1. Gonadorelin
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Gonadorelin is also known as Gonadotropin-Releasing Hormone (GnRH), and it plays a major role in the body’s endocrine system as a peptide hormone.
As such, it’s crucial for helping to regulate the creation and release of two key hormones in the body, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), which both originate in the pituitary gland.1
These hormones are essential components for reproductive health and also have an indirect impact on the production of GH.
The mechanism of action of Gonadorelin involves stimulating the pituitary and prompting it to release LH and FSH, whose release can lead to an elevated rate of testosterone release in males and estrogen in females.2
Both testosterone and estrogen contribute to a natural boost in the body’s GH levels, and the relationship between these two sex hormones and GH is critical since balanced levels of each are known to support optimal GH production.
Gonadorelin’s benefits go beyond the regulation of key hormones.
It’s used in therapies related to reproductive health and fertility, such as delayed puberty and conditions like hypogonadism, which highlights just how versatile it is.
Finally, it’s prized in fitness and bodybuilding circles for its ability to naturally optimize hormone levels, supporting muscle growth, recovery, and overall physical development.
#2. Ipamorelin
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Next up on our list of the best HGH peptides is none other than a compound called Ipamorelin.
Ipamorelin is a peptide that stands out as a highly selective GH secretagogue, which makes it one of the best peptides available for stimulating HGH production and release.
Unlike many other peptides in this class, Ipamorelin specifically targets the pituitary gland to release the Gh without having significant effects on other hormones, such as cortisol.
The mechanism of action behind Ipamorelin’s effectiveness involves mimicking a natural hormone, ghrelin, and binding to the ghrelin receptors.
By binding to these receptors, Ipamorelin stimulates the secretion of GH from the pituitary gland.
This highly targeted approach makes it one of the most attractive choices for those seeking the benefits of boosted HGH levels without the broader hormonal changes that are typically seen with other peptides.3
Ipamorelin is also known for promoting lean muscle growth, enhancing muscle recovery, and improving overall body composition.4
The ability of Ipamorelin to stimulate GH release naturally makes it an interesting peptide to research for anti-aging purposes.
Higher HGH levels can directly contribute to improved skin elasticity, higher bone density, and enhanced energy levels.
Additionally, due to the specificity of Ipamorelin, it does not significantly increase appetite, which is a common side effect of many other GH-releasing peptides, making it one of the best options out there.
#3. CJC-1295
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CJC-1295 is a synthetic GHRH analog that has gained a significant amount of attention for its ability to boost HGH levels.
The mechanism of action of CJC-1295 is centered around stimulation of the pituitary gland, leading to an increase in HGH as well as insulin-like growth factor 1, IGF-1, in the bloodstream.
Unlike other GHRH peptide options, CJC-1295 has the unique feature of a greater half-life, making it have a longer time of action and more prolonged effects compared to others.5
This extended-release is primarily due to a modification that binds to albumin in the bloodstream, extending the half-life and duration of action.
As a result, CJC-1295 also does not cause sudden spikes in HGH levels but instead provides a more natural and steady release of GH.
This steadier release is a benefit that makes it a very attractive option for those seeking long-term benefits in their muscle growth plans, along with fat loss and overall health improvement.
#4. BPC-157
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Another one of the best HGH peptides is BPC-157.
BPC-157 is short for Body Protecting Compound-157, and it’s a peptide that is renowned for its incredible healing properties.
While not a conventional GHRH, BPC-157 indirectly contributes to the body’s growth hormone activity by boosting healing, which is critical for overall health and physical development.
This peptide is derived from a special protein found in stomach secretions and has shown considerable indications that it can help accelerate the healing of many different types of injuries to different tissues, including muscle, tendon, and nerve tissues.
BPC-157 works by enhancing the natural healing processes already present in the body by promoting angiogenesis, and the formation of new blood vessels, which are critical components for healing damaged tissue.6
This leads not only to faster healing but also to a more efficient nutrient supply and waste removal from healing tissues, speeding up the healing process even further.
The potential benefits of BPC-157 for athletes and others partaking in intense physical activities are substantial.7
Faster recovery means less downtime and less downtime means more consistent training.
While not directly contributing to GH secretion, BPC-157’s role in the natural healing processes makes it a critical supplement for GH maintenance.
#5. GHRP-6
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GHRP-6 is also known as Growth Hormone-Releasing Peptide 6, and it’s a potent stimulator of GH production and release.
GHRP-6 is primarily known for its effects on helping boost appetite for those looking to gain mass, and the primary action is to stimulate the pituitary by mimicking the natural hormone ghrelin, where it triggers a series of reactions that leads to GH release.8
GHRP-6 is ideal for professional bodybuilders and athletes who need help increasing muscle mass and want to do it through a combination of GH stimulation and increased caloric intake.9
#6. Sermorelin
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Sermorelin is a synthetic analog of growth hormone-releasing hormone, GHRH, and is widely used to stimulate HGH production and release.
It’s particularly noteworthy for its efficacy in anti-aging treatment as well as its ability to mimic the natural GHRH by stimulating the pituitary to release HGH.
The structure of Sermorelin is very similar to that of natural GHRH, which allows it to more effectively bind to the GHRH receptors in the pituitary gland and promote effective HGH secretion.10
Using Sermorelin for HGH release is a more physiological approach compared to directly supplementing HGH.
That said, this method ensures a much more controlled and gradual increase in the baseline HGH levels, which helps it align more closely with the body’s natural rhythm.
Sermorelin helps enhance lean muscle mass, improve the body’s composition, and promote more efficient fat metabolism, along with boosting energy levels, improving sleep quality, and enhancing overall well-being.11
Sermorelin also has a role in anti-aging therapies that is relatively substantial.
By boosting HGH levels that naturally decline with advancing age, Sermorelin is able to help mitigate some of the natural effects of aging like lower muscle mass and bone density.
Sermorelin’s ability to stimulate natural HGH production without typical HGH supplementation side effects makes it one of the leading choices for anyone looking for a balanced approach to hormone therapy.
#7. GHRP-2
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GHRP-2, or Growth Hormone-Releasing Peptide 2, is another entry in the GHRP family that has gained attention for its ability to stimulate HGH production.
Just like GHRP-6, GHRP-2 is a fully synthetic agonist of ghrelin, the hormone that regulates appetite and GH secretion.
However, GHRP-2 is typically considered more potent and it has less of an appetite-stimulating effect compared to GHRP-6.
GHRP-2 works by directly stimulating the pituitary gland to release an increased level of GH, which is beneficial for muscle growth, fat loss, and injury recovery.12
GHRP-2 is known to be particularly effective in boosting lean body mass and improving the body’s natural recovery process, helping to enhance overall athletic performance.
One of the biggest benefits of GHRP-2 is that it can stimulate GH production and release without significantly raising cortisol or prolactin levels.
Both of these are hormones that can have adverse effects when present in the system in elevated amounts.
This is what makes GHRP-2 a more appealing choice for individuals looking to harness additional HGH, without dealing with the potential drawbacks of increased appetite or other hormonal imbalances.
Combined, GHRP-2's effectiveness in boosting HGH levels and its milder effect on appetite make it a powerful tool in the bodybuilder’s toolkit.
#8. Follistatin
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Follistatin is a unique peptide that’s known for its potent muscle-building properties.
Unlike many other GH-releasing peptides, Follistatin directly influences muscle growth and development by inhibiting or blocking myostatin, which is a protein that specifically restricts muscle growth.
By blocking myostatin, Follistatin is able to promote significant muscle growth and substantial strength gains, making it one of the most sought-after peptides in the bodybuilding and athletic communities.13
Follistatin’s mechanism of action is centered around its interaction with myostatin and similar growth factors, and by binding to and neutralizing myostatin.
Follistatin can remove the natural limits the body puts on muscle growth.14
This leads to greater muscle hypertrophy and can be specifically beneficial for individuals looking to achieve substantial mass gains and muscle strength.
Other than muscle growth, Follistatin has shown indications that it can promote tissue repair by lowering inflammation, thereby contributing to faster recovery and shorter overall recovery times following injury or intense activity.
Follistatin’s unique way of enhancing muscle growth without directly altering HGH levels makes it one of the most distinctive and potentially potent supplements for those seeking an edge in adding mass and boosting muscle development.
Conclusion
The landscape of HGH-stimulating peptides is diverse and offers a wide array of options to choose from, each with unique benefits and mechanisms of action.
From Gonadorelin to Follistatin, each of these peptides is able to provide a pathway to boosted GH levels, increased muscle growth, recovery, and elevated well-being.
While Gonadorelin and Sermorelin mimic natural hormonal processes, peptides like Ipamorelin and CJC-1295 offer targeted HGH stimulation, allowing users to tailor their approach to meet individual health and wellness goals.
If you’re considering any of these peptides, it’s critical to understand how they work, their potential benefits, and how to use them correctly and safely.
Remember to always consult with a healthcare provider of choice and consider not only your personal goals but your lifestyle and more when choosing the right peptide for you.
As research continues to evolve, these peptides and more will continue to offer intriguing avenues for health and wellness enhancement, fitness improvement, and elevated quality of life.
References
- Martínez M, Mapletoft RJ, Kastelic JP, Carruthers T. The effects of 3 gonadorelin products on luteinizing hormone release, ovulation, and follicular wave emergence in cattle. Can Vet J. 2003 Feb;44(2):125-31. PMID: 12650040; PMCID: PMC340045.
- Kesler DJ, Summers RN, Peterson CA, Steckler TL. Gonadorelin-induced testosterone release: a biological assay for quality assurance of gonadorelin in veterinary medicine. Drug Dev Ind Pharm. 1999 Mar;25(3):315-21. doi: 10.1081/ddc-100102176. PMID: 10071824.
- Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
- Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.
- Alba M, Fintini D, Sag
- azio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. PMID: 16822960.
- Vukojevic J, Milavić M, Perović D, Ilić S, Čilić AZ, Đuran N, Štrbe S, Zoričić Z, Filipčić I, Brečić P, Seiverth S, Sikirić P. Pentadecapeptide BPC 157 and the central nervous system. Neural Regen Res. 2022 Mar;17(3):482-487. doi: 10.4103/1673-5374.320969. PMID: 34380875; PMCID: PMC8504390.
- Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014 Nov 19;19(11):19066-77. doi: 10.3390/molecules191119066. PMID: 25415472; PMCID: PMC6271067.
- Lei T, Buchfelder M, Fahlbusch R, Adams EF. Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells. J Mol Endocrinol. 1995 Feb;14(1):135-8. doi: 10.1677/jme.0.0140135. PMID: 7772238.
- Mendoza Marí Y, Fernández Mayola M, Aguilera Barreto A, García Ojalvo A, Bermúdez Alvarez Y, Mir Benítez AJ, Berlanga Acosta J. Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds. Plast Surg Int. 2016;2016:4361702. doi: 10.1155/2016/4361702. Epub 2016 Apr 20. PMID: 27200188; PMCID: PMC4854984.
- Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. doi: 10.2165/00063030-199912020-00007. PMID: 18031173.
- Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-8. doi: 10.2147/ciia.2006.1.4.307. PMID: 18046908; PMCID: PMC2699646.
- Laferrère B, Abraham C, Russell CD, Bowers CY. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005 Feb;90(2):611-4. doi: 10.1210/jc.2004-1719. PMID: 15699539; PMCID: PMC2824650.
- Iyer CC, Chugh D, Bobbili PJ, Iii AJB, Crum AE, Yi AF, Kaspar BK, Meyer KC, Burghes AHM, Arnold WD. Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function. Neurobiol Aging. 2021 Aug;104:32-41. doi: 10.1016/j.neurobiolaging.2021.03.005. Epub 2021 Mar 12. PMID: 33964607; PMCID: PMC8225567.
- Kota J, Handy CR, Haidet AM, Montgomery CL, Eagle A, Rodino-Klapac LR, Tucker D, Shilling CJ, Therlfall WR, Walker CM, Weisbrode SE, Janssen PM, Clark KR, Sahenk Z, Mendell JR, Kaspar BK. Follistatin gene delivery enhances muscle growth and strength in nonhuman primates. Sci Transl Med. 2009 Nov 11;1(6):6ra15. doi: 10.1126/scitranslmed.3000112. PMID: 20368179; PMCID: PMC2852878.
